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A single intake of sildenafil at a dose of 100 mg at the same time as erythromycin - a specific inhibitor of CYP3A4 when taking erythromycin at 500 mg twice in 5 days - against the background of reaching a constant concentration of erythromycin in the blood leads to an increase in AUC sildenafil by 182.
Two individuals could ingest an oral dose of 30 mg DXM, yet one user is likely to eliminate the drug along with its dextrorphan metabolite faster than the other individual.
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